Daily curated COVID-19 literature
WP11 - The objective of this work package is to respond to requests concerning the current scientific knowledge on SARS-CoV-2. Based on the latest scientific literature the team will compile findings and give advice when needed
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
Expert Summary: The authors determined the x-ray crystal structure of a key protein of SARS-CoV-2 life cycle: the main protease, Mpro, and its complex with an α-ketoamide inhibitor. On this basis, they developed the lead compound into a potent inhibitor of the SARS-CoV-2 Mpro protease.
Antimalarials widely used against COVID-19 heighten risk of cardiac arrest. How can doctors minimize the danger?
Expert Summary: Evidence starts arising that chloroquine and hydroxychloroquine have potentially fatal side effects, causing a type of irregular heart rhythm that can lead to cardiac arrest. More research is needed to evaluate the safety profile of this drug in the context of SARS-CoV-2 infection.