Daily curated COVID-19 literature
WP11 - The objective of this work package is to respond to requests concerning the current scientific knowledge on SARS-CoV-2. Based on the latest scientific literature the team will compile findings and give advice when needed
Expert Summary: The editors of Nature Medicine warn that the COVID-19 crisis and the measures taken to slow down and prevent the expansion of the virus, although necessary, have taken a toll on the population's mental health and well-being. Measures such as quarantine can cause depression, insomnia and emotional disturbance for example. The authors call for researchers working in social and behavioral sciences and psychologists to work together to address the mental-health needs under this pandemic context.
Expert Summary: In this brief, Nature Medicine summarizes the most important research from this week (24 April to 1 May, 2020): status of clinical trials and advances in testing and diagnosis.
Expert Summary: In this brief, Nature Medicine summarizes the most important research from this week (11 to 17 April, 2020): new clinical trials, advances in the research of possible neutralizing antibodies, epidemiological studies and structural analysis of SARS-CoV-2 providing new possible targets for drugs.
Expert Summary: The authors report temporal patterns of virus shedding and modelled infectiousness profiles from transmission pairs. They estimate that viral shedding peaked on or before symptom onset and a substantial proportion of transmission might occur before first symptoms. Criteria to include tracing to individuals in contact with the patient 2 to 3 days before symptom onset must be considered for effective control of the outbreak.
Expert Summary: The authors present broad guidelines for an EXIT strategy essentially based on three points: 1. Maintenance of social distancing measures; 2. Comprehensive Testing (PCR-based and serological testing) for identification of infected and immune individuals, with implementation of isolation and contact tracing measures; 3. Upscaling of diagnostic capacity for progressive de-confinement of groups based on transmission and risk profile. The authors also mention the crucial need to protect inidivudals at high risk, exempting them from returning to work in a first phase.
Expert Summary: Summary of the most important publications about COVID-19 on the week of 4th-10th April: plasma therapy trial at Johns Hopkins Univerty, anti-IL-6 receptor monoclonal antibody (tocilizumab), low levels of neutralizing antibodies against SARS-CoV-2 of patients recovered from the infection, recombinant ACE2 enzyme in clinical trials, reports on co-morbodities associated with higher fatality in ICU.
A framework for identifying regional outbreak and spread of COVID-19 from one-minute population-wide surveys
Expert Summary: The authors propose a tool that allows daily 1-minute population-wide surveys in order to trace COVID-19 infections. This tool would allow the assessment of development of symptoms caused by the virus and identifification of clusters of COVID-19 spread. The data be used by epidemiologists, public-health officials and policymakers. The authors show preliminary results from an Israeli survey of a cumulative number of over 74,000 responses and call for additional countries to join an international consortium to extend this concept in order to develop predictive models.