Daily curated COVID-19 literature
WP11 - The objective of this work package is to respond to requests concerning the current scientific knowledge on SARS-CoV-2. Based on the latest scientific literature the team will compile findings and give advice when needed
COVID-19 Research in Brief: 30 May to 5 June, 2020
Expert Summary: Nature Medicine summarizes all the research you need to know this week to keep on top of how science is responding to the COVID-19 pandemic.
COVID-19 Research in Brief: 23 May to 29 May, 2020
Expert Summary: Nature Medicine summarizes the new advances and publication on COVID-19 on the week prior. Last week there was progress in the field of clinical and pre-clinical studies.
COVID-19 Research in Brief: 9 May to 15 May, 2020
Expert Summary: Nature Medicine summarizes all the research you need to know of last week to keep on top of how science is responding to the COVID-19 pandemic.
Infection of bat and human intestinal organoids by SARS-CoV-2
Expert Summary: The authors establish and characterize expandable intestinal organoids derived from horseshoe bats that can recapitulate bat intestinal epithelium. These bat enteroids are fully susceptible to SARS-CoV-2 infection and sustain robust viral replication. Furthermore, the viral replication in human intestinal organoids suggests that the human intestinal tract might be a transmission route of SARS-CoV-2.
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
Expert Summary: The authors analyzed bronchoalveolar lavage fluid immune cells from patients with COVID-19 by single-cell RNA sequencing. In patients with severe syptoms, proinflammatory monocyte-derived macrophages were abundant. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells.
A serological assay to detect SARS-CoV-2 seroconversion in humans
Expert Summary: Description of a serological assay for the screening and identification of human SARS-CoV-2 seroconverters. This assay does not require the handling of infectious virus, can be adjusted to detect different antibody types in serum and plasma and it can be scaled up.
Real-time tracking of self-reported symptoms to predict potential COVID-19
Expert Summary: The authors analysed data from 2 million users of a smartphone-based app designed for large-scale tracking of potential COVID-19 symptoms. The results show that loss of taste and smell sensations is predictive of potential SARS-CoV-2 infection and can be part of routine screening for COVID-19.
Modeling shield immunity to reduce COVID-19 epidemic spread
Expert Summary: The authors have developed an epidemiological intervention model that would bring "shield immunity" at the population scale. The model aims to sustain the interactions necessary for the functioning of essential goods and services while reducing the probability of transmission. The authors highlight the need for serological tests and the potential development of plasma-based therapies.