50 projects
Status
Domain
Organization Type
COVID-19 and Neurturin
SARS-Cov-2 is a coronavirus is at the origin of the current COVID-19 pandemic, which poses a global and significant threat to public health worldwide. Although several treatment modalities have been evaluated, none has allowed a therapeutic breakthrough until now. New treatment modalities are therefore urgently needed. We have previously described that neurturin, a member of the glial cell line-derived neurotrophic factor family, expressed not only as a growth factor in the nervous system but also the immune system, displays clear anti-inflammatory properties in mouse asthma models. Indeed,...
COVID19-induced changes to the plasma proteome
Studies focussing on human coronavirus found so far seven different viruses including SARS, MERS and COVID19. SARS, MERS and COVID19 present with various flu-like symptoms up to respiratory distress. Secondary symptoms include kidney problems, cardiovascular problems and neurological signs, like headache and nausea. In the case of the SARS infection, it has been shown that the virus can invade the central nervous system in patients and laboratory animals. The infection of epithelial cells by a coronavirus will lead to a change of the cellular protein composition in response to the virus' ...
Cell-cell interaction model of COVID19 for potential interventions
The emergence of COVID-19 pandemic implies new challenges for the Health Systems worldwide. The great majority of COVID-19 infections are mild and self-limiting in nature. Nevertheless, a small percentage of the patients require hospitalisation and specialised attention in Intensive Care Units (ICUs). The role of host immune responses in clearance of COVID-19 or the role, if any, of host immune responses in contributing to severe respiratory pathogenesis of COVID-19 infections is not known at this time. There are previously identified specific host immune response chemokine and cytokine sig...
Communication4Care
In a nutshell: Communication4Care (Com4Care) is a cloud-based communication platform to facilitate GDPR conform interoperability and link of relevant (sensor) data with structured patient-related information. No data files need to be exchanged and the platform provides a secure data storage and (real time or asynchronous) communication channel. Thus, improved standardized data acquisition, process monitoring, and data interpretation are possible. The patient can collect and report individual findings and outcomes (PROMs) and 'distribution of information' or sending of data files (electronic...
Comparing the technical performances of three real-time PCR protocols to counteract the COVID-19 ...
The outbreak of SARS-CoV-2 infections has underlined the critical value of laboratory diagnosis in order to quickly identify infected-patients, to provide optimized care, and to limit COVID-19 transmission. Several real-time RT-PCR diagnostic assays were rapidly developped, in particular by pharmaceutical companies which were Conformité Européenne (CE) marked. Since all countries are currently facing reagent shortages that limit the testing capacity, several real-time PCR assays were established to counteract the COVID-19 outbreak by using different techniques and suppliers, such as in Lu...
Controling the symptoms
Since the information about the COVID-19 pandemic isn't that much available. The easiest and fastest way to mitigate the virus is by controlling the symptoms.
Cytokines as biomarkers and therapeutic targets in COVID-19 infection
Cytokines play an important role in the pathogenesis of COVID-19 infection. A subgroup of patients develops a cytokine storm syndrome, correlating with a bad clinical outcome. For example, the concentration of the inflammatory cytokine Interleukin-6 (IL-6) has been recognized as a risk factor for mortality and for respiratory failure in Chinese and German patient cohorts, respectively. Tocilizumab, an antibody directed against the IL-6 receptor alpha chain, is used in clinical trials as well as an FDA-approved inhibitor of Jaks, tyrosine kinases which mediate the signal transduction of mult...
DICO-Lux: DIgital Covid-19 Observatory In LUXembourg: An Open Tool For SARS-COV-2 Crisis Manageme...
Monitoring online activities for public health purposes has been investigated since the first days of the digital epidemiology field early 2010s, with the objective of capturing health-related trends and model disease outbreaks. Most famous examples of internet surveillance were developed for the flu, influenza AH1N1, the Zika virus or Ebola. We now have the opportunity to leverage both the digital data available online and the appropriate Natural Language Processing (NLP) and Text Mining methods to fight the Covid-19 pandemic. The main objective of the DICO-LUX project is to rapidly d...