4 projects
Status
Domain
Organization Type
COVID-19 and chronic diseases: national health care provider survey
COVID-19 is placing unprecedented pressures on healthcare systems. The current declared pandemic has urged healthcare professionals to reorganise profoundly their everyday practice while trying to maintain care for other patients. Since the 'lockdown' situation in Luxembourg, changes in the medical sector include the opening of advanced care centres, promotion of teleconsultations and restrictions on non-urgent health care. Pre-existing chronic diseases such as cancer, cardiovascular and respiratory disease are reported as being major risk factor for severe COVID-19 health outcomes (Jordan ...
A novel high throughput assay to measure plasma neutralizing activity against SARS-CoV2
To date, there is no vaccine and no specific antiviral agent against SARS-CoV-2. Because of hospital saturation, controversial drug efficiency and the risk of medicinal shortage, there is an urgent need for alternative treatment options. Passive (plasmapheresis) and active immunization (vaccine) approaches aim to provide or elicit a protective humoral immune response against SARS-CoV-2. This project aims to develop a high throughput assay to measure the neutralizing activity of COVID-19 patients. It will help characterize the antibody response against SARS-CoV-2, and select the sera with hi...
Development of a high performance COVID-19 immunoassay to assess population-based viral immunity
The current situation of lock-down in many countries creates a strong need for large screening efforts in order to assess the immune status of the population and to advice decision makers on measures to relaunch social and economic activites. Due to the need for serological testing on high numbers of individuals over several months, shortages are predictable and a major threat to society. The present proposal aims at the setup of a diagnostic assay using an immunodetection technique and recombinant viral surface proteins expressed and purified in Luxembourg. This assay will allow Luxembourg...
Multi-omics evaluation of microbial co-infection as marker of COVID-19 severity -(CO-INFECTOMICS)
The main goal of this project is to understand if SARS-CoV2 co-infections are a predictive marker of disease severity in the Luxembourgish population. To achieve this, the study will compare the respiratory and stool samples of mild and severe SARS-CoV2 positive patients. Using metagenomics and metatranscriptomics, microbial profiles of the respiratory and intestinal tracts will be investigated, with a specific attention for co-infections. Moreover, individual microbial profiles will be correlated to the health parameters and immune response. We hope that the CO-INFECTOMICS project will ena...
