37 projects

Relation of severity of COVID-19 infection to nutrient status, oxidative stress, inflammation & v...

Background: Severity of COVID-19 infection is related to host-factors including the immune and respiratory system, gut health, and pre-existing cardio-metabolic diseases. Enhanced inflammation and oxidative stress may worsen the prognosis of COVID-19 subjects. An imbalanced diet poor in essential micronutrients, dietary fiber and phytochemicals and containing insufficient proteins and antioxidant properties can aggravate these aspects, worsening the immune system and infection risk, especially in conjunction with enhanced visceral adiposity exacerbating chronic inflammation. Individuals wit...

Communication4Care

In a nutshell: Communication4Care (Com4Care) is a cloud-based communication platform to facilitate GDPR conform interoperability and link of relevant (sensor) data with structured patient-related information. No data files need to be exchanged and the platform provides a secure data storage and (real time or asynchronous) communication channel. Thus, improved standardized data acquisition, process monitoring, and data interpretation are possible. The patient can collect and report individual findings and outcomes (PROMs) and 'distribution of information' or sending of data files (electronic...

Peptide / protein /single-cell map of the renin-angiotensin system in Covid-19

Receptors for entry of SARS-CoV-2 into lung pneumocytes belong to the renin-angiotensin system and disease that are associated to a dysregulation of the same system (e.g.: diabetes, hypertension, and cardiovascular diseases) are thought to be associated with a bad Covid-19 prognosis. At the same time these receptor are also expressed on cells of the immune system and the immune system is involved in diseases associated to RAS dysregulation. Our project wish to use an integrated mass spectrometry / flow cytometry approach to build a map of the RAS at the peptide and protein level together w...

Screening for small molecule activators of mesenchymal stem cells as potential therapeutics for C...

Some COVID-19 patients have been successfully treated with mesenchymal stem cells. Most probably, the positive effect comes from the immunomodulatory function of mesenchymal stem cells on the inflammatory burst in the virus-damaged alveolar region. An already established 3D in vitro model representing the alveolar barrier will be enriched with mesenchymal stem cells to further increase the similarity to the human in vivo situation. We suggest to use these alveolar models as a tool to screen for small molecules that activate endogenous mesenchymal stem cells and that have therefore therapeut...

Identifying Predictors of Disease Progression and Tracking Viral Spread in COVID-19 Using Contin...

COVID-19 presents several unique challenges within cardiovascular care. While patients with preexisting CVD appear to be at an increased risk for severe disease and/or death, infection has also been shown to produce a number of CV sequelae, including cardiogenic shock and heart failure, in patients with no known CVD. Further complicating the management of cardiovascular care in COVID-19 are the adverse cardiovascular side effects produced by nearly all investigational therapies currently being tested, as well as, the unknown effects of standard care therapies used for the management of pree...

ExpertEye

Leveraging medical expertise is in times of the COVID-19 pandemic a world challenge. Tele-medicine, the remote delivery of healthcare services through technology, can be a solution. The goal of project 'ExpertEye' is to provide tele-medicine for COVID-19 scenarios such that the onsite care practitioners receive live and handsfree expert interactive medical feedback, while simultaneously acting on the feedback and implementing the advice to the patient in front of them. ExpertEye, used with Smart Glasses, aids in the communication between healthcare personnel working in a negative pressure r...

COVID19-induced changes to the plasma proteome

Studies focussing on human coronavirus found so far seven different viruses including SARS, MERS and COVID19. SARS, MERS and COVID19 present with various flu-like symptoms up to respiratory distress. Secondary symptoms include kidney problems, cardiovascular problems and neurological signs, like headache and nausea. In the case of the SARS infection, it has been shown that the virus can invade the central nervous system in patients and laboratory animals. The infection of epithelial cells by a coronavirus will lead to a change of the cellular protein composition in response to the virus' ...

MicroRNA biomarkers of COVID-19 severity

The Cardiovascular Research Unit of LIH proposes to apply its know-how on RNA biomarkers to identify circulating microRNAs (miRNAs) able to predict COVID-19 severity. This project is included in COVID-19 Task force WP02 and aims to fulfill the medical need of identifying patients at high risk of developing complications after infection by SARS-CoV-2 virus. The discovery of novel prognostic biomarkers will help tailoring healthcare to each individual for patient's benefit. Considering the importance of the inflammatory storm on disease severity and patient outcome, we will focus on inflamma...

export results as excel

MESR FNR University of Luxembourg LIST LISER LIH