37 projects

Enabling technology for Portable, Rapid, Label-Free, PCR-Less detection of Viral RNA

Reliable detection of the presence of an infection at early stages, even before symptoms appear, is a non-trivial challenge, one that requires delivering high sensitivity in detection of viral RNA. Further, a detection at the point of care, at response times of few minutes using disposable sensors would deliver a practical solution to de-centralized mass-testing of subjects. From an industry point of view, such technology should also be practical enough to be produced and implemented in large quantities using tools that do not have to be customized. The cost of the measurement should be lo...

A PRECLINICAL EVALUATION: VACCINATION AND EFFICACY AGAINST SARS-CoV-2

SARS-CoV-2, the causative factor of COVID-19, is endangering the world's health, prosperity and political crises are on the horizon. Nations worldwide had to take drastic measures to prevent catastrophes: strict confinement and hygienic measures have been undertaken to minimize the virus spread. Despite the control measures, the pandemic is inevitably damaging the economy due to a shutdown of public and business life, an overload of the healthcare systems, and the high case fatality rate of COVID-19. The global fight against COVID-19 has mobilized, and many provisional treatments are being ...

COVID-19 and Neurturin

SARS-Cov-2 is a coronavirus is at the origin of the current COVID-19 pandemic, which poses a global and significant threat to public health worldwide. Although several treatment modalities have been evaluated, none has allowed a therapeutic breakthrough until now. New treatment modalities are therefore urgently needed. We have previously described that neurturin, a member of the glial cell line-derived neurotrophic factor family, expressed not only as a growth factor in the nervous system but also the immune system, displays clear anti-inflammatory properties in mouse asthma models. Indeed,...

Hormonal status as predictor of Covid-19 infection severity (HorCovIS)

Among people infected by COVID 19, significant disparities have been observed regarding the severity of the symptoms. Although some factors such as the presence of comorbidities have been pointed out, for another part of the patients the high severity of the symptoms remains unexplained. The HorCoVIS project aims at assessing how the hormonal status of the patients prior to infection, could be linked to symptoms severity and possibly used as a predictive tool of specific measures necessity in newly infected patients.

Direct detection of SARS-CoV-2 RNA with field effect transistors

The current methods for COVID-19 diagnosis suffer shortages of fundamental reagents and lack of reliability. The main, most secure, method is PCR, with high sensitivity, though it has some lack of reliability due to inefficiencies in the RNA transcription, and the sensitivities to virus mutations. Though, the main bottleneck is the shortage of enzymes during the current pandemic. The second group of methods are less reliable rapid serologic tests, which are sensitive only after 7 days of infection. It is also limited by the availability of antibodies. We propose direct detection of RNA usin...

Rapid serological profiling of SARS-CoV-2 antibody response

Development of antibodies is the method by which we derive immunity to a pathogen. Tracking of the development of antibodies to SARS-CoV-2 (Covid-19) is important in our understanding of this pandemic and formation of an exit strategy. Antibodies can identify different parts or proteins of a pathogen known as antigens. Current tests do not distinguish which antigens antibodies have been developed against or the level of antibody production. Using protein arrays, printed at the LIH RPPA facility we will provide a more complete analysis of the antibody development.

Comparing the technical performances of three real-time PCR protocols to counteract the COVID-19 ...

The outbreak of SARS-CoV-2 infections has underlined the critical value of laboratory diagnosis in order to quickly identify infected-patients, to provide optimized care, and to limit COVID-19 transmission. Several real-time RT-PCR diagnostic assays were rapidly developped, in particular by pharmaceutical companies which were Conformité Européenne (CE) marked. Since all countries are currently facing reagent shortages that limit the testing capacity, several real-time PCR assays were established to counteract the COVID-19 outbreak by using different techniques and suppliers, such as in Lu...

Cell-cell interaction model of COVID19 for potential interventions

The emergence of COVID-19 pandemic implies new challenges for the Health Systems worldwide. The great majority of COVID-19 infections are mild and self-limiting in nature. Nevertheless, a small percentage of the patients require hospitalisation and specialised attention in Intensive Care Units (ICUs). The role of host immune responses in clearance of COVID-19 or the role, if any, of host immune responses in contributing to severe respiratory pathogenesis of COVID-19 infections is not known at this time. There are previously identified specific host immune response chemokine and cytokine sig...

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