37 projects

COVID-19 DIAGNOSTIC PROGRAM POWERED BY AI

The aim of the project is to create a prototype of an integrated tele-medical system supporting comprehensive clinical decisions in the field of novel COVID-19. The project scope also includes significant research activities focused on utilising a variety of available multidisciplinary clinical and imaging data to enable the proposed system to go beyond supporting detection and diagnosis that is already possible by the existing methods. The problem undertaken in the project is the limitations related to the early diagnosis of the COVID-19, collection of epidemiological and statistical data ...

Pocket Rehab - mHealth-based Rehabilitation Program for patients with cardiovascular disease as p...

Cardiovascular diseases remain the major cause of mortality with an estimated prevalence of 422.7 million cases worldwide at high cost for the public health. Recently, the pathophysiological mechanism of the coronavirus uses the angiotensin-converting enzyme 2 (ACE2) as a functional receptor, increasing the risk of contamination and the mortality rate in this population, aggravating this scenario. According to the epidemiological bulletin of COE-COVID19 of the Ministry of Health of Brazil, among the 1124 deaths recorded until 11 April 2020, in those under the age of 60, 82.5% had illness a...

The new breathing therapy method based on short-term intermittent exposure to hypoxia in rehabili...

The current worldwide healthcare focus is on countering acute COVID-19 effects in emergency care patients. However, two distinct SARS-CoV-2 syndrome phases have been already identified: while the first acute phase is characterised by a prevalent respiratory syndrome, the second one which accompanies gradual respiratory syndrome recovery is marked by a prolonged bed rest syndrome and invasive mechanical ventilation sequelae. This means that following the acute infection stage, worldwide health services will have to cope with the significant secondary issue, namely large numbers of patients...

COVI-NUTRI-METABOLOMICS

Background: A poor nutrient status due to sub-optimal dietary habits increases risk of viral infections. In particular, individuals with low vitamin D, A and E, as well as zinc plasma levels are less likely to develop immune-responses against influenza vaccines. Vitamin C supplementation improves conditions in individuals with acute respiratory infections in some studies. Dietary fiber is inversely correlated with mortality from respiratory/infectious disease. These nutrients are paramount for optimal immune-response, are implicated in oxidative stress, inflammatory processes, and viral rep...

Impact of hypoxia on COVID-19 infection in lung epithelial cells

The international spread of coronavirus disease 2019 (COVID-19) has recently caused over 120.000 deaths in Europe and 200.000 worldwide. The clinical picture goes from the absence of symptoms to critical conditions requiring admission to resuscitation units. The molecular pathways involved in COVID-19 infection and pathogenesis are still being explored. 'Silent hypoxia' is considered by some physicians as an early indicator of COVID-19 viral infection in patients. A key step in COVID-19 infection is the viral entry into pulmonary alveoli epithelial cells, leading to the disruption of surf...

Digital Health Passport

With the lockdown exit, all public places must allow the safe reception of a large part of the population. To do this, it will be essential to detect symptomatic individuals, while respecting their rights and dignity, in order to protect them, but also protect others. We propose a Digital Health Passport (DHP), a mobile application, which is part of this process. The citizen will therefore have at hand a sesame which will allow him to integrate the public places of his choice. This DHP will contain information about his state of health, only that related to the Covid 19, namely the results ...

Covid-19 related LOckdown: Shift in Exposures to neighbourhood environments and changes in Physic...

A lockdown state implies radical changes in our lifestyle, especially physical activity (PA), while PA plays a central role in maintaining an adequate health status, counteracting the negative consequences of numerous diseases. We aim to investigate the impact of lockdown (and quarantine) on PA patterns based on retrospective data. We will analyse the intra-individual changes in PA patterns of participants stratified in two specific subgroups of interest, namely positive cases and their household members as a result of the lockdown/quarantine measures in place, with respect to the partici...

Comparative antiviral efficacy of different autophagy inhibitors against COVID-19 infection

As of April 28, 2020, worldwide, over 3 million people have been diagnosed and over 211,000 deaths with ongoing deadly coronavirus disease-19 (COVID-19) also known as SARS coronavirus 2 (SARS-CoV-2/2019-nCoV). Currently, there is no approved treatment against COVID-19. Vaccines are under development, but they will take at least one year before reaching to the population. A fast track approach would be to reuse already approved drugs that have been broadly tested through multiple clinical trials. Virophagy is a catabolic autophagic pathway used by mammalian cells to destroy viruses. Viruses ...

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