114 projects

HUMAN GENETIC VARIANTS AS PREDICTORS OF THE IMMUNE RESPONSE TO COVID-19

One of the main unanswered questions is why some individuals infected with COVID-19 develop severe disease, whilst others do not. Current evidence suggests that genetic variations influence human immune reactions to microbial infections, including both innate and adaptive immune responses. Here, we aim to evaluate the impact of genetic factors on the variability of the innate immune response to SARS-CoV-2 infection. On top of a large screening of the classical immune response genes (e.g. IFNs, ILs, TLRs, MHCs), we are particularly interested in the IRG1/ACOD1 gene, which we previously di...

Monitoring system for epidemiologcal exposure person to person (MEEP2P)

In case of epidemics, where human contacts are the main vector for spreading a contagion, there is a need to track human mobility patterns and interactions in order to trace back how an infected person interacted with other people over a certain time moment. Besides, tacking into account the privacy of users and making sure that access of the data is allowed only with the consent of users and only during well-defined conditions (limited in time of a pandemics) is essential for a democratic society. Our proposal aims at developing such a solution that can achieve a good tradeoff between tr...

TrapNclean

Some studies have demonstrated that SARS-CoV is stable almost 2 weeks after drying in standard air conditions and 3 weeks in a liquid environment. Therefore the role of fomites and environmental contamination play a significant role in virus transmission. It has been shown that Coronaviridae is less stable in high humidity and can be easily killed by heating at 56C during 15mn. We propose a solution which combines high temperature at high humidity as a synergistic inactivation of COVID19. A functional coating could be applied to masks, filtering systems for respiratory masks or gloves in...

Real-time Social Distancing Analysis

The idea of this project is to analyse if the Social Distancing measures decided by the government are being respected by the general population. To do so we propose to analyse anonymised video data in the City of Luxembourg.

Investigating hindbrain infection by SARS-CoV-2

Emerging reports suggest an infection of the hindbrain, which e.g. regulates the unconscious breathing process, by SARS-CoV-2. Some patients report that they have to breath actively/conscious. We suggest to use hindbrain organoids, infect them with the virus, investigate phenotypes and test candidate small molecules.

How much do respirators protect healthcare workers from COVID19?

In the context of the current Covid-19 pandemic, it became clear that while performing treatment procedures on contaminated patients, medical personnel could be exposed to SARS-CoV-2 virus. Respirators (intended to protect the healthcare workers) provide a tight seal with the face of the wearer, and must meet rigorous standards on high filtration efficiencies and rigorous certification. In Europe, respirators such as FFP1, FFP2 and FFP3 are certificated by 'Conformité Européenne' (CE) in order to meet filtration efficiencies of 80%, 94% and 99% against particles of 0.3µm, respectively. Taki...

Low-cost breath sensors for SARS-CoV-2 for home usage

Based on our research on liquid crystal droplets and shells demonstrating their responsiveness to specific substances in their surrounding, e.g. lipids, I would like to explore the possibility of making low-cost tests for SARS-CoV-2 that people can use in their home. We also make polymer fibers in our labs, and by using the right polymer, we can make a filter that a persons breathers through (mounted in, e.g., a face mask), and then the filter is dissolved in water, which is the natural surrounding for our liquid crystal droplets and spheres. If viruses have been caught in the filter, they ...

Spark Project- Sharing cultural Heritage

An invitation to individual and community to share a component of their culture through a short web post. It will help people who receive it to open themselves to other realities. A recurring post proposiition will create a feeling of journey by staying in quarantine. It will help to soft better the current hard time. In some way to give hope in the future and refrain fearing the stranger.

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