22 projects
Status
Domain
Organization Type
MicroRNA biomarkers of COVID-19 severity
The Cardiovascular Research Unit of LIH proposes to apply its know-how on RNA biomarkers to identify circulating microRNAs (miRNAs) able to predict COVID-19 severity. This project is included in COVID-19 Task force WP02 and aims to fulfill the medical need of identifying patients at high risk of developing complications after infection by SARS-CoV-2 virus. The discovery of novel prognostic biomarkers will help tailoring healthcare to each individual for patient's benefit. Considering the importance of the inflammatory storm on disease severity and patient outcome, we will focus on inflamma...
HUMAN GENETIC VARIANTS AS PREDICTORS OF THE IMMUNE RESPONSE TO COVID-19
One of the main unanswered questions is why some individuals infected with COVID-19 develop severe disease, whilst others do not. Current evidence suggests that genetic variations influence human immune reactions to microbial infections, including both innate and adaptive immune responses. Here, we aim to evaluate the impact of genetic factors on the variability of the innate immune response to SARS-CoV-2 infection. On top of a large screening of the classical immune response genes (e.g. IFNs, ILs, TLRs, MHCs), we are particularly interested in the IRG1/ACOD1 gene, which we previously di...
Investigating hindbrain infection by SARS-CoV-2
Emerging reports suggest an infection of the hindbrain, which e.g. regulates the unconscious breathing process, by SARS-CoV-2. Some patients report that they have to breath actively/conscious. We suggest to use hindbrain organoids, infect them with the virus, investigate phenotypes and test candidate small molecules.
Low-cost breath sensors for SARS-CoV-2 for home usage
Based on our research on liquid crystal droplets and shells demonstrating their responsiveness to specific substances in their surrounding, e.g. lipids, I would like to explore the possibility of making low-cost tests for SARS-CoV-2 that people can use in their home. We also make polymer fibers in our labs, and by using the right polymer, we can make a filter that a persons breathers through (mounted in, e.g., a face mask), and then the filter is dissolved in water, which is the natural surrounding for our liquid crystal droplets and spheres. If viruses have been caught in the filter, they ...
Development of a MS-based COVID19 test
The project aims on developing an alternative test for the detection of corona virae based on proteomic methods. The advatage of the use of proteins is that the samples do not have to be cooled and can be transported at room temperature to the analytical lab.
Controling the symptoms
Since the information about the COVID-19 pandemic isn't that much available. The easiest and fastest way to mitigate the virus is by controlling the symptoms.
