2 projects
Status
Domain
Organization Type
Ultra-high sensitivity biochemical and cellular assays for diagnostics and drug discovery against...
Sensitive detection of biomolecules is the cornerstone of diagnostic and drug discovery assays in COVID-19/ SARS-CoV-2 research. Two workpackages (3 and 4) within this special LuxCOVID-19 call focus on these areas. While diagnostic assays need to be cheap, fast and reliable, drug discovery assays ideally have a strong predictive power for efficacy. Our group has developed a palette of molecular assays in the past years, in order to detect binding of small molecules or peptides to protein pockets or to protein-protein interfaces. We have a particular expertise in providing complementary in ...
Rapid serological profiling of SARS-CoV-2 antibody response
Development of antibodies is the method by which we derive immunity to a pathogen. Tracking of the development of antibodies to SARS-CoV-2 (Covid-19) is important in our understanding of this pandemic and formation of an exit strategy. Antibodies can identify different parts or proteins of a pathogen known as antigens. Current tests do not distinguish which antigens antibodies have been developed against or the level of antibody production. Using protein arrays, printed at the LIH RPPA facility we will provide a more complete analysis of the antibody development.
