8 projects
Status
Domain
Organization Type
COVID-19 DIAGNOSTIC PROGRAM POWERED BY AI
The aim of the project is to create a prototype of an integrated tele-medical system supporting comprehensive clinical decisions in the field of novel COVID-19. The project scope also includes significant research activities focused on utilising a variety of available multidisciplinary clinical and imaging data to enable the proposed system to go beyond supporting detection and diagnosis that is already possible by the existing methods. The problem undertaken in the project is the limitations related to the early diagnosis of the COVID-19, collection of epidemiological and statistical data ...
Covid-19 related LOckdown: Shift in Exposures to neighbourhood environments and changes in Physic...
A lockdown state implies radical changes in our lifestyle, especially physical activity (PA), while PA plays a central role in maintaining an adequate health status, counteracting the negative consequences of numerous diseases. We aim to investigate the impact of lockdown (and quarantine) on PA patterns based on retrospective data. We will analyse the intra-individual changes in PA patterns of participants stratified in two specific subgroups of interest, namely positive cases and their household members as a result of the lockdown/quarantine measures in place, with respect to the partici...
Host genetics of COVID-19
The COVID-19 pandemic is a global crisis creating severe disruptions across the economy and health system. Known risk factors for severe forms of COVID-19 disease include age, male sex, and comorbidities such as diabetes, hypertension, and cardiovascular diseases. Irrespective of these risk factors, some succumbing to the disease are previously healthy and relatively young. Hence, it has been hypothesized that the genetic background of the individuals might play a role in this differential immune response. In order to understand the role of genetics in COVID-19 immune response, the internat...
Investigating the role of COmpanion and LIVEstock animals in the Epidemiology of SARS-CoV-2 in Lu...
Almost all Coronaviruses (CoVs) affecting human, including human CoV-NL63, -229E, -OC43, SARS-CoV and MERS-CoV, have a zoonotic origin. Similarly, phylogenetic and recombination analyses strongly suggested a zoonotic origin for SARS-CoV-2. After adaptation to human, some zoonotic viruses retain the capacity of infecting animals, as regularly shown for influenza A virus. There is a raising concern that SARS-CoV-2 virus may have a host switching potential as well. Anecdotic cases already suggest that Canidae and Felidae are susceptible to SARS-CoV-2 infection. Experimental intranasal infectio...
Rapid serological profiling of SARS-CoV-2 antibody response
Development of antibodies is the method by which we derive immunity to a pathogen. Tracking of the development of antibodies to SARS-CoV-2 (Covid-19) is important in our understanding of this pandemic and formation of an exit strategy. Antibodies can identify different parts or proteins of a pathogen known as antigens. Current tests do not distinguish which antigens antibodies have been developed against or the level of antibody production. Using protein arrays, printed at the LIH RPPA facility we will provide a more complete analysis of the antibody development.
Relation of severity of COVID-19 infection to nutrient status, oxidative stress, inflammation & v...
Background: Severity of COVID-19 infection is related to host-factors including the immune and respiratory system, gut health, and pre-existing cardio-metabolic diseases. Enhanced inflammation and oxidative stress may worsen the prognosis of COVID-19 subjects. An imbalanced diet poor in essential micronutrients, dietary fiber and phytochemicals and containing insufficient proteins and antioxidant properties can aggravate these aspects, worsening the immune system and infection risk, especially in conjunction with enhanced visceral adiposity exacerbating chronic inflammation. Individuals wit...
Low-cost breath sensors for SARS-CoV-2 for home usage
Based on our research on liquid crystal droplets and shells demonstrating their responsiveness to specific substances in their surrounding, e.g. lipids, I would like to explore the possibility of making low-cost tests for SARS-CoV-2 that people can use in their home. We also make polymer fibers in our labs, and by using the right polymer, we can make a filter that a persons breathers through (mounted in, e.g., a face mask), and then the filter is dissolved in water, which is the natural surrounding for our liquid crystal droplets and spheres. If viruses have been caught in the filter, they ...
Controling the symptoms
Since the information about the COVID-19 pandemic isn't that much available. The easiest and fastest way to mitigate the virus is by controlling the symptoms.
