Emerging reports suggest an infection of the hindbrain, which e.g. regulates the unconscious breathing process, by SARS-CoV-2. Some patients report that they have to breath actively/conscious. We suggest to use hindbrain organoids, infect them with the virus, investigate phenotypes and test candidate small molecules.
Based on our research on liquid crystal droplets and shells demonstrating their responsiveness to specific substances in their surrounding, e.g. lipids, I would like to explore the possibility of making low-cost tests for SARS-CoV-2 that people can use in their home. We also make polymer fibers in our labs, and by using the right polymer, we can make a filter that a persons breathers through (mounted in, e.g., a face mask), and then the filter is dissolved in water, which is the natural surrounding for our liquid crystal droplets and spheres. If viruses have been caught in the filter, they ...
The project aims on developing an alternative test for the detection of corona virae based on proteomic methods. The advatage of the use of proteins is that the samples do not have to be cooled and can be transported at room temperature to the analytical lab.
Since the information about the COVID-19 pandemic isn't that much available. The easiest and fastest way to mitigate the virus is by controlling the symptoms.
Accumulating evidence suggests that a subgroup of patients with severe COVID-19 might have a cytokine storm syndrome that leads to hyperinflammation of their lung tissue. Challenge is how to interrupt this hyperinflammation without critically suppressing immune system. SkQ1 compound developed by Mitotech SA (Luxembourg) has shown to interrupt cytokine storm in animal models and may be irreplaceable in preventing fatalities in COVID-19.