69 projects

Identifying Predictors of Disease Progression and Tracking Viral Spread in COVID-19 Using Contin...

COVID-19 presents several unique challenges within cardiovascular care. While patients with preexisting CVD appear to be at an increased risk for severe disease and/or death, infection has also been shown to produce a number of CV sequelae, including cardiogenic shock and heart failure, in patients with no known CVD. Further complicating the management of cardiovascular care in COVID-19 are the adverse cardiovascular side effects produced by nearly all investigational therapies currently being tested, as well as, the unknown effects of standard care therapies used for the management of pree...

ExpertEye

Leveraging medical expertise is in times of the COVID-19 pandemic a world challenge. Tele-medicine, the remote delivery of healthcare services through technology, can be a solution. The goal of project 'ExpertEye' is to provide tele-medicine for COVID-19 scenarios such that the onsite care practitioners receive live and handsfree expert interactive medical feedback, while simultaneously acting on the feedback and implementing the advice to the patient in front of them. ExpertEye, used with Smart Glasses, aids in the communication between healthcare personnel working in a negative pressure r...

COVAMBU: Multi-centre, adaptive, randomized trial of the safety and efficacy of treatments of COV...

The purpose of this Multi-centre, adaptive, randomized trial is to provide substantial evidence on the efficacy, or lack of efficacy and safety of treatments available in Luxembourg, given to COVID-19 positive-testing-patients who do not yet require hospitalization. Efficacy will be assessed through virological response and clinical outcomes.

Innovative end-to-end solution for respiratory diseases detection and genotyping

Our innovative end-to-end solution for respiratory diseases detection and genotyping is composed of 3 main compoenets as follows: First, we want, through a multiplex qPCR assay, to target and differentiate in priority COVID-19, SARS, H5N1, H1N1 (devastating diseases) from seasonal flu (under control). Second, we propose to develop an NGS and SANGER assay for the following Intended uses: Respiratory diseases Genotyping, Screening, Monitoring, Quasispecies identification, Epidemiological studies. Third, we target to establish a large COVID-19 and SARS worldwide database , compare patient ...

Prophylaxis: Chloroquine or hydroxychloroquine prevention of COVID-19 disease for caregivers in L...

The aim of this clinical trial is to determine if prophylactic chloroquine or hydroxychloroquine prevents symptomatic COVID-19 illness health care workers in Luxembourg. The secondary objectives include: • Attenuation of the clinical severity of COVID-19 infections. • The prevention of asymptomatic COVID-19. • The prevention of symptomatic all-cause acute respiratory illnesses (ARI).

COVID19-induced changes to the plasma proteome

Studies focussing on human coronavirus found so far seven different viruses including SARS, MERS and COVID19. SARS, MERS and COVID19 present with various flu-like symptoms up to respiratory distress. Secondary symptoms include kidney problems, cardiovascular problems and neurological signs, like headache and nausea. In the case of the SARS infection, it has been shown that the virus can invade the central nervous system in patients and laboratory animals. The infection of epithelial cells by a coronavirus will lead to a change of the cellular protein composition in response to the virus' ...

MicroRNA biomarkers of COVID-19 severity

The Cardiovascular Research Unit of LIH proposes to apply its know-how on RNA biomarkers to identify circulating microRNAs (miRNAs) able to predict COVID-19 severity. This project is included in COVID-19 Task force WP02 and aims to fulfill the medical need of identifying patients at high risk of developing complications after infection by SARS-CoV-2 virus. The discovery of novel prognostic biomarkers will help tailoring healthcare to each individual for patient's benefit. Considering the importance of the inflammatory storm on disease severity and patient outcome, we will focus on inflamma...

HUMAN GENETIC VARIANTS AS PREDICTORS OF THE IMMUNE RESPONSE TO COVID-19

One of the main unanswered questions is why some individuals infected with COVID-19 develop severe disease, whilst others do not. Current evidence suggests that genetic variations influence human immune reactions to microbial infections, including both innate and adaptive immune responses. Here, we aim to evaluate the impact of genetic factors on the variability of the innate immune response to SARS-CoV-2 infection. On top of a large screening of the classical immune response genes (e.g. IFNs, ILs, TLRs, MHCs), we are particularly interested in the IRG1/ACOD1 gene, which we previously di...

export results as excel

MESR FNR University of Luxembourg LIST LISER LIH