69 projects

COVID-19 and chronic diseases: national health care provider survey

COVID-19 is placing unprecedented pressures on healthcare systems. The current declared pandemic has urged healthcare professionals to reorganise profoundly their everyday practice while trying to maintain care for other patients. Since the 'lockdown' situation in Luxembourg, changes in the medical sector include the opening of advanced care centres, promotion of teleconsultations and restrictions on non-urgent health care. Pre-existing chronic diseases such as cancer, cardiovascular and respiratory disease are reported as being major risk factor for severe COVID-19 health outcomes (Jordan ...

COVI-NUTRI-METABOLOMICS

Background: A poor nutrient status due to sub-optimal dietary habits increases risk of viral infections. In particular, individuals with low vitamin D, A and E, as well as zinc plasma levels are less likely to develop immune-responses against influenza vaccines. Vitamin C supplementation improves conditions in individuals with acute respiratory infections in some studies. Dietary fiber is inversely correlated with mortality from respiratory/infectious disease. These nutrients are paramount for optimal immune-response, are implicated in oxidative stress, inflammatory processes, and viral rep...

iTECare

Nosocomial infection represents (at European level) 5 million cases, 135,000 deaths with a cost between 13 and 24 billion euros. iTECare is a startup dedicated to develop, produce and distribute ecological disinfection solutions facilitating decontamination, ensuring employee safety, reassuring clients and avoiding new outbreaks • UV-C desinfection lamps able to sterilize in 2 minutes (instead of 20 minutes) an hospital room, hotel room, a meeting room, an office, a cloths shop. The UV-C lamp emits very useful ultraviolet radiation at the wavelength of 253.7 nm, which destroys the DNA & ...

Impact of hypoxia on COVID-19 infection in lung epithelial cells

The international spread of coronavirus disease 2019 (COVID-19) has recently caused over 120.000 deaths in Europe and 200.000 worldwide. The clinical picture goes from the absence of symptoms to critical conditions requiring admission to resuscitation units. The molecular pathways involved in COVID-19 infection and pathogenesis are still being explored. 'Silent hypoxia' is considered by some physicians as an early indicator of COVID-19 viral infection in patients. A key step in COVID-19 infection is the viral entry into pulmonary alveoli epithelial cells, leading to the disruption of surf...

Digital Health Passport

With the lockdown exit, all public places must allow the safe reception of a large part of the population. To do this, it will be essential to detect symptomatic individuals, while respecting their rights and dignity, in order to protect them, but also protect others. We propose a Digital Health Passport (DHP), a mobile application, which is part of this process. The citizen will therefore have at hand a sesame which will allow him to integrate the public places of his choice. This DHP will contain information about his state of health, only that related to the Covid 19, namely the results ...

Covid-19 related LOckdown: Shift in Exposures to neighbourhood environments and changes in Physic...

A lockdown state implies radical changes in our lifestyle, especially physical activity (PA), while PA plays a central role in maintaining an adequate health status, counteracting the negative consequences of numerous diseases. We aim to investigate the impact of lockdown (and quarantine) on PA patterns based on retrospective data. We will analyse the intra-individual changes in PA patterns of participants stratified in two specific subgroups of interest, namely positive cases and their household members as a result of the lockdown/quarantine measures in place, with respect to the partici...

Comparative antiviral efficacy of different autophagy inhibitors against COVID-19 infection

As of April 28, 2020, worldwide, over 3 million people have been diagnosed and over 211,000 deaths with ongoing deadly coronavirus disease-19 (COVID-19) also known as SARS coronavirus 2 (SARS-CoV-2/2019-nCoV). Currently, there is no approved treatment against COVID-19. Vaccines are under development, but they will take at least one year before reaching to the population. A fast track approach would be to reuse already approved drugs that have been broadly tested through multiple clinical trials. Virophagy is a catabolic autophagic pathway used by mammalian cells to destroy viruses. Viruses ...

BioOrg eliminate the virus on surfaces and weaken spreading

BioOrg is a natural ecosystem initially destined to purify indoor air quality and facilitate natural cleaning. It is made of bacteria naturally present in our forest. No allergens, no additives except perfume for a safe use in all environment. Very simple : fine spraying in indoor spaces (buildings, vehicles, homes) will create a natural ecosystem. Bacteria in the solution will digest fine particles (aggressive to the lungs and carrier of COVID-19), solvants, and other indoor polluters. Bacillius bacteria are known for years to dry out surfaces by digesting biomass, thus creating a hostil...

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