3 projects

COVI-NUTRI-METABOLOMICS

Background: A poor nutrient status due to sub-optimal dietary habits increases risk of viral infections. In particular, individuals with low vitamin D, A and E, as well as zinc plasma levels are less likely to develop immune-responses against influenza vaccines. Vitamin C supplementation improves conditions in individuals with acute respiratory infections in some studies. Dietary fiber is inversely correlated with mortality from respiratory/infectious disease. These nutrients are paramount for optimal immune-response, are implicated in oxidative stress, inflammatory processes, and viral rep...

Functional characterization of COVID-19 patient gut microbiome

While COVID-19 is mainly considered an airway and lung disease, up to 79% of patients present with gastrointestinal symptoms and recent studies report on the presence of SARS-CoV-2 viral RNA and particles in stools of infected patients, suggesting that the gastrointestinal (GI) tract may have a more important role in disease pathology or transmission than previously thought. The GI tract is also the site of the dense and diverse microbiome, which has the ability to regulate intestinal and systemic immunity through the conversion of dietary nutrients into bioactive metabolites. Consequently,...

Relation of severity of COVID-19 infection to nutrient status, oxidative stress, inflammation & v...

Background: Severity of COVID-19 infection is related to host-factors including the immune and respiratory system, gut health, and pre-existing cardio-metabolic diseases. Enhanced inflammation and oxidative stress may worsen the prognosis of COVID-19 subjects. An imbalanced diet poor in essential micronutrients, dietary fiber and phytochemicals and containing insufficient proteins and antioxidant properties can aggravate these aspects, worsening the immune system and infection risk, especially in conjunction with enhanced visceral adiposity exacerbating chronic inflammation. Individuals wit...

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