198 projects

Impact of hypoxia on COVID-19 infection in lung epithelial cells

The international spread of coronavirus disease 2019 (COVID-19) has recently caused over 120.000 deaths in Europe and 200.000 worldwide. The clinical picture goes from the absence of symptoms to critical conditions requiring admission to resuscitation units. The molecular pathways involved in COVID-19 infection and pathogenesis are still being explored. 'Silent hypoxia' is considered by some physicians as an early indicator of COVID-19 viral infection in patients. A key step in COVID-19 infection is the viral entry into pulmonary alveoli epithelial cells, leading to the disruption of surf...

Digital Health Passport

With the lockdown exit, all public places must allow the safe reception of a large part of the population. To do this, it will be essential to detect symptomatic individuals, while respecting their rights and dignity, in order to protect them, but also protect others. We propose a Digital Health Passport (DHP), a mobile application, which is part of this process. The citizen will therefore have at hand a sesame which will allow him to integrate the public places of his choice. This DHP will contain information about his state of health, only that related to the Covid 19, namely the results ...

Covid-19 related LOckdown: Shift in Exposures to neighbourhood environments and changes in Physic...

A lockdown state implies radical changes in our lifestyle, especially physical activity (PA), while PA plays a central role in maintaining an adequate health status, counteracting the negative consequences of numerous diseases. We aim to investigate the impact of lockdown (and quarantine) on PA patterns based on retrospective data. We will analyse the intra-individual changes in PA patterns of participants stratified in two specific subgroups of interest, namely positive cases and their household members as a result of the lockdown/quarantine measures in place, with respect to the partici...

Organizing detection of Covid-19 through mobile app and web portal

In order to prevent new waves of Covid-19 epidemic infections, detection of the virus among the population appears as a strong tool. This would allow to identify active cases (with or without symptoms) that would stay isolated, not-yet infected people that could still be infected, and recovered patients that would be protected against a new infection. This clustering of population by detection, which is essential in an exit strategy, has to be supported by efficient logistic structures and information to population. We propose the creation of a web portal coupled to a public application tha...

Digital travel certificate for frontier workers

The Covid-19 pandemic brought a large number of territories to confine populations to slow the spread of the virus. The special status of frontier workers has led several states, including Luxembourg, to require the production of a specific. This is signed by the employer so that workers from neighboring countries can enter the territory on a professional basis. In Luxembourg, this certificate currently in paper format is valid for the entire duration of confinement. We propose the creation of a web portal (and a mobile app) allowing the generation of a digital movement certificate for cros...

Comparative antiviral efficacy of different autophagy inhibitors against COVID-19 infection

As of April 28, 2020, worldwide, over 3 million people have been diagnosed and over 211,000 deaths with ongoing deadly coronavirus disease-19 (COVID-19) also known as SARS coronavirus 2 (SARS-CoV-2/2019-nCoV). Currently, there is no approved treatment against COVID-19. Vaccines are under development, but they will take at least one year before reaching to the population. A fast track approach would be to reuse already approved drugs that have been broadly tested through multiple clinical trials. Virophagy is a catabolic autophagic pathway used by mammalian cells to destroy viruses. Viruses ...

Covid-19, Politics and Religion

The proposed interdisciplinary research will elaborate on the impact of COVID-19 on the social operation of religion at a Luxembourgish and European level. The research is divided in a theoretical and an empirical part. The theoretical part aims at identifying the place of religion as an element within the dominant discourse on COVID-19.The empirical approach will explore the potential changes in religiosity after COVID-19, as well as their possible reflection in party politics. In particular, it will explore the following research themes: a) The possible effect of COVID-19 on public opi...

BioOrg eliminate the virus on surfaces and weaken spreading

BioOrg is a natural ecosystem initially destined to purify indoor air quality and facilitate natural cleaning. It is made of bacteria naturally present in our forest. No allergens, no additives except perfume for a safe use in all environment. Very simple : fine spraying in indoor spaces (buildings, vehicles, homes) will create a natural ecosystem. Bacteria in the solution will digest fine particles (aggressive to the lungs and carrier of COVID-19), solvants, and other indoor polluters. Bacillius bacteria are known for years to dry out surfaces by digesting biomass, thus creating a hostil...

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