198 projects
Status
Organization Type
Visual Public Protection Disaster Relief and Critical Infrastructure
The aim of the Visual PCI project is to develop an IT platform to assist crisis managers and critical infrastructure planners. The platform will provide a new approach to risk assessment and will visually present the essential elements of Public Protection and Disaster Recovery (PPDR) resources and the Critical Infrastructure (CI) functions as required by crisis management and Critical Infrastructure Protection (CIP) and planning. Real time data input will provide situational awareness. Simulations will support planning and crisis management by considering population behaviour as well as de...
COVID19-induced changes to the plasma proteome
Studies focussing on human coronavirus found so far seven different viruses including SARS, MERS and COVID19. SARS, MERS and COVID19 present with various flu-like symptoms up to respiratory distress. Secondary symptoms include kidney problems, cardiovascular problems and neurological signs, like headache and nausea. In the case of the SARS infection, it has been shown that the virus can invade the central nervous system in patients and laboratory animals. The infection of epithelial cells by a coronavirus will lead to a change of the cellular protein composition in response to the virus' ...
Yes we care - Oral history with health workers in Luxembourg
While the social and economic consequences of the Covid pandemic cannot yet be determined, there is no longer any doubt that it is a 'historic event'. The C2DH has therefore embarked on a collection of different sources that are currently being produced. A team has begun to collect testimonies from people working in the medical and health care sector. The pandemic is indeed shedding light on how the hospital and care systems function. Flattening the curve in order to allow the health system to cope with covid19 was, and is, one the defining slogans of the pandemic. The project, which has...
MESSEQ - MEthodology for Simulation and Selection of Economic Quarantine exit scenarios
Introduction - One of the main challenges in the crisis period we are going through is to choose the right scenario for leaving quarantine or even resuming partial quarantine if necessary. The scenarios to be analysed must combine public health and economic and social impact. Such an initiative should be carried out in collaboration with government decision-making bodies such as Ministry of Economy, HCPN... Objective - This project would then make it possible to simulate and test all the possible scenarios for a gradual exit from containment while limiting the risk of contagion and optimis...
MicroRNA biomarkers of COVID-19 severity
The Cardiovascular Research Unit of LIH proposes to apply its know-how on RNA biomarkers to identify circulating microRNAs (miRNAs) able to predict COVID-19 severity. This project is included in COVID-19 Task force WP02 and aims to fulfill the medical need of identifying patients at high risk of developing complications after infection by SARS-CoV-2 virus. The discovery of novel prognostic biomarkers will help tailoring healthcare to each individual for patient's benefit. Considering the importance of the inflammatory storm on disease severity and patient outcome, we will focus on inflamma...
HUMAN GENETIC VARIANTS AS PREDICTORS OF THE IMMUNE RESPONSE TO COVID-19
One of the main unanswered questions is why some individuals infected with COVID-19 develop severe disease, whilst others do not. Current evidence suggests that genetic variations influence human immune reactions to microbial infections, including both innate and adaptive immune responses. Here, we aim to evaluate the impact of genetic factors on the variability of the innate immune response to SARS-CoV-2 infection. On top of a large screening of the classical immune response genes (e.g. IFNs, ILs, TLRs, MHCs), we are particularly interested in the IRG1/ACOD1 gene, which we previously di...
Monitoring system for epidemiologcal exposure person to person (MEEP2P)
In case of epidemics, where human contacts are the main vector for spreading a contagion, there is a need to track human mobility patterns and interactions in order to trace back how an infected person interacted with other people over a certain time moment. Besides, tacking into account the privacy of users and making sure that access of the data is allowed only with the consent of users and only during well-defined conditions (limited in time of a pandemics) is essential for a democratic society. Our proposal aims at developing such a solution that can achieve a good tradeoff between tr...
TrapNclean
Some studies have demonstrated that SARS-CoV is stable almost 2 weeks after drying in standard air conditions and 3 weeks in a liquid environment. Therefore the role of fomites and environmental contamination play a significant role in virus transmission. It has been shown that Coronaviridae is less stable in high humidity and can be easily killed by heating at 56C during 15mn. We propose a solution which combines high temperature at high humidity as a synergistic inactivation of COVID19. A functional coating could be applied to masks, filtering systems for respiratory masks or gloves in...
