198 projects

COVID-19 and air quality - effects and interactions

Against the background of the global COVID-19 outbreak and the increasing number of confirmed infections Europe, a shutdown of all non-essential businesses took place. Besides lower emissions from industries the amount of traffic declined significantly, especially in regions with a high commuter amounts. Traffic is an important source of fine particles, and due to their size and chemical composition they pose a high risk to human health. On a global scale PM has led to >3.3 million premature deaths and has been associated with diseases like acute lower respiratory illness or COPD. Furtherm...

CRISIS - Correlates of Resilience In the context of Social Isolation in Seniors

In the current COVID-19 crisis, older adults are at particular risk for severe health outcomes and increased mortality. Whereas it is of prime importance to raise public awareness regarding the special risk of older people, and reduced in-person contact is essential to protect vulnerable groups, we have to take into account what effects these measures have on subjective well-being, mental health and further development of older persons. The present research project will tackle the question of how current measures and their communication to the public are experienced by the target group (60...

OPEN LABEL RANDOMIZED CONTROLLED TRIAL OF THE SAFETY AND EFFICACY OF PLASMA THERAPY FROM RECOVERE...

In December 2019, the Wuhan Municipal Health Committee identified an outbreak of viral pneumonia cases of unknown cause. Coronavirus RNA was quickly identified in some of these patients. This novel coronavirus has been designated SARS-CoV-2, and the disease caused by this virus has been designated COVID-19. Currently there are no approved therapeutic agents available for coronaviruses. The purpose of this trial is to provide substantial evidence on the efficacy and safety of the treatment of selected COVID-19 patients with plasma obtained from convalescent COVID-19 patients ('PLASMA').

DAPASOL - LIST Data Analytics Platform as a Service for Covid 19 crisis Solutions

The project wants to maximise the use of relevant data to manage the COVID 19 crisis by building an infrastructure that supports collaboration and alleviates most technical obstacles linked to data management, including: - data processing (acquisition, storage, curation, harvesting, descriptive analysis, e.g. trend, noise vs information, outliers, etc., or visualisation); - integration of data with other available sources, including from the public domain, data lakes or from partners and external contributors; - providing access to LIST Data analytics Platform and services in an incremen...

Digoxin in COVID-19 combination therapy

Providing Digoxin to be incorporated in clinical trials that test combination of drugs, to to assess the benefits of Digoxin in treating COVID-19.

Screening for small molecule activators of mesenchymal stem cells as potential therapeutics for C...

Some COVID-19 patients have been successfully treated with mesenchymal stem cells. Most probably, the positive effect comes from the immunomodulatory function of mesenchymal stem cells on the inflammatory burst in the virus-damaged alveolar region. An already established 3D in vitro model representing the alveolar barrier will be enriched with mesenchymal stem cells to further increase the similarity to the human in vivo situation. We suggest to use these alveolar models as a tool to screen for small molecules that activate endogenous mesenchymal stem cells and that have therefore therapeut...

Identifying Predictors of Disease Progression and Tracking Viral Spread in COVID-19 Using Contin...

COVID-19 presents several unique challenges within cardiovascular care. While patients with preexisting CVD appear to be at an increased risk for severe disease and/or death, infection has also been shown to produce a number of CV sequelae, including cardiogenic shock and heart failure, in patients with no known CVD. Further complicating the management of cardiovascular care in COVID-19 are the adverse cardiovascular side effects produced by nearly all investigational therapies currently being tested, as well as, the unknown effects of standard care therapies used for the management of pree...

ExpertEye

Leveraging medical expertise is in times of the COVID-19 pandemic a world challenge. Tele-medicine, the remote delivery of healthcare services through technology, can be a solution. The goal of project 'ExpertEye' is to provide tele-medicine for COVID-19 scenarios such that the onsite care practitioners receive live and handsfree expert interactive medical feedback, while simultaneously acting on the feedback and implementing the advice to the patient in front of them. ExpertEye, used with Smart Glasses, aids in the communication between healthcare personnel working in a negative pressure r...

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