198 projects

Rapid Development and Initial Preclinical Evaluation of an Effective Candidate Vaccine against SARS-CoV-2

The current pandemic caused by SARS-CoV-2 is a threat not only to global health but also to the economy since it is dramatically affecting the socioeconomic layers of societies around the planet. Thus, it will be critically important to advance in the production of an effective vaccine, which will be crucial for building up sufficient population-based immunity to efficiently curb the pandemic. While SARS-CoV-2 can infect everyone at all ages, it is mainly the elderly population that is most at risk of a fatal outcome. Elderly persons are charecterized by a declining immune function, known a...

Pocket Rehab - mHealth-based Rehabilitation Program for patients with cardiovascular disease as p...

Cardiovascular diseases remain the major cause of mortality with an estimated prevalence of 422.7 million cases worldwide at high cost for the public health. Recently, the pathophysiological mechanism of the coronavirus uses the angiotensin-converting enzyme 2 (ACE2) as a functional receptor, increasing the risk of contamination and the mortality rate in this population, aggravating this scenario. According to the epidemiological bulletin of COE-COVID19 of the Ministry of Health of Brazil, among the 1124 deaths recorded until 11 April 2020, in those under the age of 60, 82.5% had illness a...

FAREWELL to C19 (FAmily REsponse and WELL-Being impact of Covid-19

Lockdowns and the economic crisis induced by Covid-19 are imposing unprecedented constraints on families in terms of freedom of choice, consumption opportunities, time use, and social interaction. While working from home has become the norm, it also implies a dramatic increase in inequality among families, since people most likely to be working from home were already better off. The FAREWELL to C19 project aims to analyse how these effects concur with individual traits (such as age, gender, economic status, and resilience under uncomfortable circumstances) to shape people's preferences, eco...

Boosting COVID-19 protection with metal-free biocompatible antimicrobial coatings

As shown with the Covid-19 pandemic, coronavirus such as SARS-COV-2 are presenting a major threat due to their high transmission efficiency, their long lifetime on solid supports and their strong effect on human health. The deposition of antiviral coatings on surfaces like facemasks or door handles is a promising approach to fight against the contamination and transmission of SARS-COV-2. This idea addresses the field of 'surfaces with antiviral and antibacterial properties' for metal parts and protective facemasks. It is proposed to use metal-free coatings deposited via wet deposition techn...

Let's keep connected (revised version)

We will develop an interactive chatbot to provide support to confined people not only during the COVID19 crisis, but also after the confinement, in the exit and post-exit phase. The public authorities and some NGOs are offering support services to help people facing specific problems, and the same should be the case for the COVID19 crisis. It is of prime importance for these Luxembourgish services not to be overwhelmed by wrong enquiries, and also to be able to serve the maximum amount of enquiries. A majority of them could be targeted on same frequently asked questions. The chatbot that we...

Predicting major challenges of returning to work in Luxembourg by evaluating the impact of change...

This project is a study conducted by Pétillances, a company based in Strassen, Luxembourg, specialized in psychosocial risks prevention, trainings and organisational consultancy. This study was launched on 27th April 2020 and is still ongoing. It consists in a questionnaire evaluating how the measures taken by the Luxembourgish and cross-border governments are impacting the work organisation and what consequences it has on workers' mental health. Its first purpose is to compare the situation before the confinement measures were introduced and afterwards, for example: in what extent has ...

Support in the Luxembourg for app-based contact tracing of Covid-19 A longitudinal study using an...

In absence of cure, a lockdown exit strategy requires non-medical interventions such as social distancing to contain Covid-19 diffusion. Innovative apps for smartphones have been proposed to contain new outbreaks by quickly alert people in case of contact with infected people. Various technical solutions are available, but the basic idea is that an app in the mobile phone registers other users of the app in close proximity. If an app user is diagnosed with the coronavirus, all people who have recently been in close proximity to this person are notified immediately. Despite the evident adva...

CoVAlert - Development of an early warning system for the surveillance of the SARS-CoV-2 pandemic...

Luxembourg recently decided to test the whole population for SARS-CoV-2. The result of this immense effort will deliver 'only' a temporary snap shot and a continuous investigation difficult to. Alternatively, a retrospective investigation of pathogens in waste water enables countries to get a cost-effective and easy-to-obtain information of the country prevalence of Covid-19. First attempts have been made in this respect to identify the virus in urban wastewater as an easily accessible source to catch information of a whole community at one point, i.e. the wastewater treatment plant (WWTP) ...

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