12 projects

TraAct-DD - Track and Act with Data Donation #getout #stayout

Luxembourg is entering a gradual deconfinement phase. For this to be successful, it is critical that the country protect vulnerable people and build the trust of the population in going back to work, to school safely. It is also vital to identify asymptomatic COVID-positive patients and to wisely direct the (scarce) tests. If Luxembourg can manage this, epidemiological models indicate that a gradual release of the population may stem the pandemic and enable return to normal (#getout, #stayout). The ongoing debate at the government level indicates hesitation between blue-tooth tracing, ma...

Pocket Rehab - mHealth-based Rehabilitation Program for patients with cardiovascular disease as p...

Cardiovascular diseases remain the major cause of mortality with an estimated prevalence of 422.7 million cases worldwide at high cost for the public health. Recently, the pathophysiological mechanism of the coronavirus uses the angiotensin-converting enzyme 2 (ACE2) as a functional receptor, increasing the risk of contamination and the mortality rate in this population, aggravating this scenario. According to the epidemiological bulletin of COE-COVID19 of the Ministry of Health of Brazil, among the 1124 deaths recorded until 11 April 2020, in those under the age of 60, 82.5% had illness a...

Covid-19 related LOckdown: Shift in Exposures to neighbourhood environments and changes in Physic...

A lockdown state implies radical changes in our lifestyle, especially physical activity (PA), while PA plays a central role in maintaining an adequate health status, counteracting the negative consequences of numerous diseases. We aim to investigate the impact of lockdown (and quarantine) on PA patterns based on retrospective data. We will analyse the intra-individual changes in PA patterns of participants stratified in two specific subgroups of interest, namely positive cases and their household members as a result of the lockdown/quarantine measures in place, with respect to the partici...

Easy ambulatory diagnostic profilometry for Covid19 symptoms tracking: computed in Luxembourg

This project contributes to the following work packages: WP01: Infection prevalence, WP02: Predictive markers for covid-19 severity, WP05:real-time epidemiological data on COVID-19 positive or suspected cases treated in the ambulatory setting, WP07 : map and analyse COVID-19 incidence in Luxembourg, WP05 : exit strategy and 'controlled return to normalisation'. In order to easily track symptoms and severity of Covid19 diagnosed or suspected subjects, we propose a simple ambulatory diagnostic system for creating a functional capacity profilometry of an individual with modular approaches i...

An integrative network-based drug repurposing approach for COVID-19

We aim at analyzing the publicly available transcriptomics data generated by exposing human lung epithelial cells to SARS-CoV particles and measuring the differences in the gene expression. We will use a molecular network analysis approach to identify a set of key genes, that represent key regulators in the SARS-CoV gene expression signature. This signature will be filtered to distinguish pathological from protective responses and used to identify drugs that could potentially reverse pathological features of the disease phenotype based on the anti-correlation of known drug-response gene exp...

Understanding Immunity in COVID-19

Previously developed model of immune response [Abulikemu et al 2020] will be modified in the collaboration with model authors and used for understanding processes involved in SARS-CoV2. We will develop a systems immunology tool that stratifies the coronavirus patient population according to (i) their likelihood of developing the cytokine tornado and (ii) the tornado subtype they are subject to. It will insert individual patient information into our Abulikemu et al model [2020] and compute the implications for whether or not a flip from moderate ('acute') inflammation to a 'cytokine tornado...

AICovIX - AI based diagnosis of Covid-19 from CT/X-Ray imaging

The gold standard for Covid-19 diagnosis is RT-PCR for SARS-CoV-2 from the upper airways. This method suffers from decreased accuracy in more severe disease stages affecting the lower airways. False negative PCR tests in severe cases impose a massive risk to the health system, promoting intra-hospital disease spread in the actual pandemic situation. Reports from China indicate false negative PCR from upper airway samples in severe Covid-19 pneumonia in more than 50% of the cases. Therefore, complementary tests for the detection of these dangerous cases are urgently needed. The value of che...

A unified web-based platform for viral phylogeny, proteomics and genomics research in real-time

We propose the development of an integrated web-based data exploration tool for genomics, proteomics, phylogeny, evolutionary and geographical data on SARS-CoV-2 samples from Luxembourg supporting researchers and physicians to gauge the potential impact of viral evolution on virulence and transmission dynamics but also the efficacy of molecular detection methods. Integrating different data sources and visualisation modes through a graphical web-interface will offer a unique perspective on the pathogen and serve as tools to assess potential imminent risks.

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