17 projects

A unified web-based platform for viral phylogeny, proteomics and genomics research in real-time

We propose the development of an integrated web-based data exploration tool for genomics, proteomics, phylogeny, evolutionary and geographical data on SARS-CoV-2 samples from Luxembourg supporting researchers and physicians to gauge the potential impact of viral evolution on virulence and transmission dynamics but also the efficacy of molecular detection methods. Integrating different data sources and visualisation modes through a graphical web-interface will offer a unique perspective on the pathogen and serve as tools to assess potential imminent risks.

Rapid serological profiling of SARS-CoV-2 antibody response

Development of antibodies is the method by which we derive immunity to a pathogen. Tracking of the development of antibodies to SARS-CoV-2 (Covid-19) is important in our understanding of this pandemic and formation of an exit strategy. Antibodies can identify different parts or proteins of a pathogen known as antigens. Current tests do not distinguish which antigens antibodies have been developed against or the level of antibody production. Using protein arrays, printed at the LIH RPPA facility we will provide a more complete analysis of the antibody development.

Luxembourg Weizmann Initiative

Contribution to data collection effort to inform the decision making process on the pandemic exit scenario based on the Weizmann initiative adapted to Luxembourg

Relation of severity of COVID-19 infection to nutrient status, oxidative stress, inflammation & v...

Background: Severity of COVID-19 infection is related to host-factors including the immune and respiratory system, gut health, and pre-existing cardio-metabolic diseases. Enhanced inflammation and oxidative stress may worsen the prognosis of COVID-19 subjects. An imbalanced diet poor in essential micronutrients, dietary fiber and phytochemicals and containing insufficient proteins and antioxidant properties can aggravate these aspects, worsening the immune system and infection risk, especially in conjunction with enhanced visceral adiposity exacerbating chronic inflammation. Individuals wit...

DICO-Lux: DIgital Covid-19 Observatory In LUXembourg: An Open Tool For SARS-COV-2 Crisis Manageme...

Monitoring online activities for public health purposes has been investigated since the first days of the digital epidemiology field early 2010s, with the objective of capturing health-related trends and model disease outbreaks. Most famous examples of internet surveillance were developed for the flu, influenza AH1N1, the Zika virus or Ebola. We now have the opportunity to leverage both the digital data available online and the appropriate Natural Language Processing (NLP) and Text Mining methods to fight the Covid-19 pandemic. The main objective of the DICO-LUX project is to rapidly d...

Innovative end-to-end solution for respiratory diseases detection and genotyping

Our innovative end-to-end solution for respiratory diseases detection and genotyping is composed of 3 main compoenets as follows: First, we want, through a multiplex qPCR assay, to target and differentiate in priority COVID-19, SARS, H5N1, H1N1 (devastating diseases) from seasonal flu (under control). Second, we propose to develop an NGS and SANGER assay for the following Intended uses: Respiratory diseases Genotyping, Screening, Monitoring, Quasispecies identification, Epidemiological studies. Third, we target to establish a large COVID-19 and SARS worldwide database , compare patient ...

Monitoring system for epidemiological exposure person to person

In case of epidemics, where human contacts are the main vector for spreading a contagion, there is a need to track human mobility patterns and interactions in order to trace back how an infected person interacted with other people over a certain time moment.

Low-cost breath sensors for SARS-CoV-2 for home usage

Based on our research on liquid crystal droplets and shells demonstrating their responsiveness to specific substances in their surrounding, e.g. lipids, I would like to explore the possibility of making low-cost tests for SARS-CoV-2 that people can use in their home. We also make polymer fibers in our labs, and by using the right polymer, we can make a filter that a persons breathers through (mounted in, e.g., a face mask), and then the filter is dissolved in water, which is the natural surrounding for our liquid crystal droplets and spheres. If viruses have been caught in the filter, they ...

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