6 projects

COVID-19 and chronic diseases: national health care provider survey

COVID-19 is placing unprecedented pressures on healthcare systems. The current declared pandemic has urged healthcare professionals to reorganise profoundly their everyday practice while trying to maintain care for other patients. Since the 'lockdown' situation in Luxembourg, changes in the medical sector include the opening of advanced care centres, promotion of teleconsultations and restrictions on non-urgent health care. Pre-existing chronic diseases such as cancer, cardiovascular and respiratory disease are reported as being major risk factor for severe COVID-19 health outcomes (Jordan ...

Covid-19 related LOckdown: Shift in Exposures to neighbourhood environments and changes in Physic...

A lockdown state implies radical changes in our lifestyle, especially physical activity (PA), while PA plays a central role in maintaining an adequate health status, counteracting the negative consequences of numerous diseases. We aim to investigate the impact of lockdown (and quarantine) on PA patterns based on retrospective data. We will analyse the intra-individual changes in PA patterns of participants stratified in two specific subgroups of interest, namely positive cases and their household members as a result of the lockdown/quarantine measures in place, with respect to the partici...

Rapid serological profiling of SARS-CoV-2 antibody response

Development of antibodies is the method by which we derive immunity to a pathogen. Tracking of the development of antibodies to SARS-CoV-2 (Covid-19) is important in our understanding of this pandemic and formation of an exit strategy. Antibodies can identify different parts or proteins of a pathogen known as antigens. Current tests do not distinguish which antigens antibodies have been developed against or the level of antibody production. Using protein arrays, printed at the LIH RPPA facility we will provide a more complete analysis of the antibody development.

Relation of severity of COVID-19 infection to nutrient status, oxidative stress, inflammation & v...

Background: Severity of COVID-19 infection is related to host-factors including the immune and respiratory system, gut health, and pre-existing cardio-metabolic diseases. Enhanced inflammation and oxidative stress may worsen the prognosis of COVID-19 subjects. An imbalanced diet poor in essential micronutrients, dietary fiber and phytochemicals and containing insufficient proteins and antioxidant properties can aggravate these aspects, worsening the immune system and infection risk, especially in conjunction with enhanced visceral adiposity exacerbating chronic inflammation. Individuals wit...

Innovative end-to-end solution for respiratory diseases detection and genotyping

Our innovative end-to-end solution for respiratory diseases detection and genotyping is composed of 3 main compoenets as follows: First, we want, through a multiplex qPCR assay, to target and differentiate in priority COVID-19, SARS, H5N1, H1N1 (devastating diseases) from seasonal flu (under control). Second, we propose to develop an NGS and SANGER assay for the following Intended uses: Respiratory diseases Genotyping, Screening, Monitoring, Quasispecies identification, Epidemiological studies. Third, we target to establish a large COVID-19 and SARS worldwide database , compare patient ...

Low-cost breath sensors for SARS-CoV-2 for home usage

Based on our research on liquid crystal droplets and shells demonstrating their responsiveness to specific substances in their surrounding, e.g. lipids, I would like to explore the possibility of making low-cost tests for SARS-CoV-2 that people can use in their home. We also make polymer fibers in our labs, and by using the right polymer, we can make a filter that a persons breathers through (mounted in, e.g., a face mask), and then the filter is dissolved in water, which is the natural surrounding for our liquid crystal droplets and spheres. If viruses have been caught in the filter, they ...

export results as excel

MESR FNR University of Luxembourg LIST LISER LIH