17 projects

AnalysisMode

We are creating a citizen science platform to allow any person, without scientific background, to be involved in the search for a COVID-19 vaccine. Our solution combines human and artificial intelligence in a model to predict vaccine candidates.

Rapid Development and Initial Preclinical Evaluation of an Effective Candidate Vaccine against SARS-CoV-2

The current pandemic caused by SARS-CoV-2 is a threat not only to global health but also to the economy since it is dramatically affecting the socioeconomic layers of societies around the planet. Thus, it will be critically important to advance in the production of an effective vaccine, which will be crucial for building up sufficient population-based immunity to efficiently curb the pandemic. While SARS-CoV-2 can infect everyone at all ages, it is mainly the elderly population that is most at risk of a fatal outcome. Elderly persons are charecterized by a declining immune function, known a...

The new breathing therapy method based on short-term intermittent exposure to hypoxia in rehabili...

The current worldwide healthcare focus is on countering acute COVID-19 effects in emergency care patients. However, two distinct SARS-CoV-2 syndrome phases have been already identified: while the first acute phase is characterised by a prevalent respiratory syndrome, the second one which accompanies gradual respiratory syndrome recovery is marked by a prolonged bed rest syndrome and invasive mechanical ventilation sequelae. This means that following the acute infection stage, worldwide health services will have to cope with the significant secondary issue, namely large numbers of patients...

Covid-19 related LOckdown: Shift in Exposures to neighbourhood environments and changes in Physic...

A lockdown state implies radical changes in our lifestyle, especially physical activity (PA), while PA plays a central role in maintaining an adequate health status, counteracting the negative consequences of numerous diseases. We aim to investigate the impact of lockdown (and quarantine) on PA patterns based on retrospective data. We will analyse the intra-individual changes in PA patterns of participants stratified in two specific subgroups of interest, namely positive cases and their household members as a result of the lockdown/quarantine measures in place, with respect to the partici...

Understanding Immunity in COVID-19

Previously developed model of immune response [Abulikemu et al 2020] will be modified in the collaboration with model authors and used for understanding processes involved in SARS-CoV2. We will develop a systems immunology tool that stratifies the coronavirus patient population according to (i) their likelihood of developing the cytokine tornado and (ii) the tornado subtype they are subject to. It will insert individual patient information into our Abulikemu et al model [2020] and compute the implications for whether or not a flip from moderate ('acute') inflammation to a 'cytokine tornado...

A dynamic model of the COVID-19 tuned for different countries: a systems-biological tool for the ...

A dynamic model of COVID-19 epidemics recently developed (video: https://youtu.be/lbsqJ1_WvmE, model: https://jjj.bio.vu.nl/models/westerhoff1/simulate/, ref: https://medrxiv.org/cgi/content/short/2020.03.29.20045039v1) will be tuned for different countries to analyze the effect of different measures in the anticipation of next epidemics. Models will be available for online simulations at JWS Online (https://jjj.bio.vu.nl/models/westerhoff1/simulate/), and used for the development of computer tutorials for systems biological studies.

Functional characterization of COVID-19 patient gut microbiome

While COVID-19 is mainly considered an airway and lung disease, up to 79% of patients present with gastrointestinal symptoms and recent studies report on the presence of SARS-CoV-2 viral RNA and particles in stools of infected patients, suggesting that the gastrointestinal (GI) tract may have a more important role in disease pathology or transmission than previously thought. The GI tract is also the site of the dense and diverse microbiome, which has the ability to regulate intestinal and systemic immunity through the conversion of dietary nutrients into bioactive metabolites. Consequently,...

A PRECLINICAL EVALUATION: VACCINATION AND EFFICACY AGAINST SARS-CoV-2

SARS-CoV-2, the causative factor of COVID-19, is endangering the world's health, prosperity and political crises are on the horizon. Nations worldwide had to take drastic measures to prevent catastrophes: strict confinement and hygienic measures have been undertaken to minimize the virus spread. Despite the control measures, the pandemic is inevitably damaging the economy due to a shutdown of public and business life, an overload of the healthcare systems, and the high case fatality rate of COVID-19. The global fight against COVID-19 has mobilized, and many provisional treatments are being ...

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