31 projects

Screening for small molecule activators of mesenchymal stem cells as potential therapeutics for C...

Some COVID-19 patients have been successfully treated with mesenchymal stem cells. Most probably, the positive effect comes from the immunomodulatory function of mesenchymal stem cells on the inflammatory burst in the virus-damaged alveolar region. An already established 3D in vitro model representing the alveolar barrier will be enriched with mesenchymal stem cells to further increase the similarity to the human in vivo situation. We suggest to use these alveolar models as a tool to screen for small molecules that activate endogenous mesenchymal stem cells and that have therefore therapeut...

Identifying Predictors of Disease Progression and Tracking Viral Spread in COVID-19 Using Contin...

COVID-19 presents several unique challenges within cardiovascular care. While patients with preexisting CVD appear to be at an increased risk for severe disease and/or death, infection has also been shown to produce a number of CV sequelae, including cardiogenic shock and heart failure, in patients with no known CVD. Further complicating the management of cardiovascular care in COVID-19 are the adverse cardiovascular side effects produced by nearly all investigational therapies currently being tested, as well as, the unknown effects of standard care therapies used for the management of pree...

Efficacity of probiotics on coronavirus in order to overcome upcoming outbreaks

The objective of this project is to develop efficient and resistant probiotic based cleaners to reduce and limit the proliferation of the coronavirus (SARS-Cov-2) responsible of the covid-19 pandemic. Hard surfaces cleaner (dedicated to hospitals and house care cleaning), as well as hands cleaner will be developed based on the synergy between probiotics formulation as well as active natural and environmentally friendly molecules designed for cleaning. Probiotics were shown to have beneficial effect on several viral diseases, while microbial based cleaning products have shown to red...

Innovative end-to-end solution for respiratory diseases detection and genotyping

Our innovative end-to-end solution for respiratory diseases detection and genotyping is composed of 3 main compoenets as follows: First, we want, through a multiplex qPCR assay, to target and differentiate in priority COVID-19, SARS, H5N1, H1N1 (devastating diseases) from seasonal flu (under control). Second, we propose to develop an NGS and SANGER assay for the following Intended uses: Respiratory diseases Genotyping, Screening, Monitoring, Quasispecies identification, Epidemiological studies. Third, we target to establish a large COVID-19 and SARS worldwide database , compare patient ...

MicroRNA biomarkers of COVID-19 severity

The Cardiovascular Research Unit of LIH proposes to apply its know-how on RNA biomarkers to identify circulating microRNAs (miRNAs) able to predict COVID-19 severity. This project is included in COVID-19 Task force WP02 and aims to fulfill the medical need of identifying patients at high risk of developing complications after infection by SARS-CoV-2 virus. The discovery of novel prognostic biomarkers will help tailoring healthcare to each individual for patient's benefit. Considering the importance of the inflammatory storm on disease severity and patient outcome, we will focus on inflamma...

HUMAN GENETIC VARIANTS AS PREDICTORS OF THE IMMUNE RESPONSE TO COVID-19

One of the main unanswered questions is why some individuals infected with COVID-19 develop severe disease, whilst others do not. Current evidence suggests that genetic variations influence human immune reactions to microbial infections, including both innate and adaptive immune responses. Here, we aim to evaluate the impact of genetic factors on the variability of the innate immune response to SARS-CoV-2 infection. On top of a large screening of the classical immune response genes (e.g. IFNs, ILs, TLRs, MHCs), we are particularly interested in the IRG1/ACOD1 gene, which we previously di...

How much do respirators protect healthcare workers from COVID19?

In the context of the current Covid-19 pandemic, it became clear that while performing treatment procedures on contaminated patients, medical personnel could be exposed to SARS-CoV-2 virus. Respirators (intended to protect the healthcare workers) provide a tight seal with the face of the wearer, and must meet rigorous standards on high filtration efficiencies and rigorous certification. In Europe, respirators such as FFP1, FFP2 and FFP3 are certificated by 'Conformité Européenne' (CE) in order to meet filtration efficiencies of 80%, 94% and 99% against particles of 0.3µm, respectively. Taki...

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