31 projects

A PRECLINICAL EVALUATION: VACCINATION AND EFFICACY AGAINST SARS-CoV-2

SARS-CoV-2, the causative factor of COVID-19, is endangering the world's health, prosperity and political crises are on the horizon. Nations worldwide had to take drastic measures to prevent catastrophes: strict confinement and hygienic measures have been undertaken to minimize the virus spread. Despite the control measures, the pandemic is inevitably damaging the economy due to a shutdown of public and business life, an overload of the healthcare systems, and the high case fatality rate of COVID-19. The global fight against COVID-19 has mobilized, and many provisional treatments are being ...

The impact of physical distance restrictions on social mixing patterns and the transmission of COVID-19

SARS-CoV-2 has infected over a million cases and resulted in more than 70,000 deaths worldwide by April 6th. Many countries have implemented physical distance restrictions in an attempt to mitigate and slow the spread of the virus. On March 18th, the Luxembourgish government declared a state of emergency closing schools and instructing residents to stay at home while avoiding any social contacts. It is crucial to evaluate whether these measures are sufficient to control the pandemic. Therefore, several countries worldwide including Luxembourg, Belgium, the Netherlands, Norway, Singapore, Un...

COVID-19 and Neurturin

SARS-Cov-2 is a coronavirus is at the origin of the current COVID-19 pandemic, which poses a global and significant threat to public health worldwide. Although several treatment modalities have been evaluated, none has allowed a therapeutic breakthrough until now. New treatment modalities are therefore urgently needed. We have previously described that neurturin, a member of the glial cell line-derived neurotrophic factor family, expressed not only as a growth factor in the nervous system but also the immune system, displays clear anti-inflammatory properties in mouse asthma models. Indeed,...

Occupational Sorting of Employees after the Lockdown

In this project we ask the following research question: What is the impact of COVID-19 lockdown on workers' sectoral and occupational allocation, wage inequality and unemployment across European regions and countries? Our goal is to quantify the labor market implications of partial annihilation of selected sectors of economic activity. By simulating scenarios of different degree of severity, we compute changes in workers' assignment to jobs, unemployment measures, and final production across sectors of regional and national economies. Our study is targeted at identifying those segments of l...

DICO-Lux: DIgital Covid-19 Observatory In LUXembourg: An Open Tool For SARS-COV-2 Crisis Manageme...

Monitoring online activities for public health purposes has been investigated since the first days of the digital epidemiology field early 2010s, with the objective of capturing health-related trends and model disease outbreaks. Most famous examples of internet surveillance were developed for the flu, influenza AH1N1, the Zika virus or Ebola. We now have the opportunity to leverage both the digital data available online and the appropriate Natural Language Processing (NLP) and Text Mining methods to fight the Covid-19 pandemic. The main objective of the DICO-LUX project is to rapidly d...

Distributional impact of the COVID-19 Crisis

The project aims to assess the costs and distributional implications of the COVID-19 outbreak in Luxembourg. It will identify those most likely to suffer from income losses, leading to more effective/efficient targeting of income support measures and improved cost estimates of COVID-19. The lack of timely available data constrains the estimation of the scale and direction of recent changes in the income distribution, which in turn constrain policymakers seeking to monitor such developments. There are huge uncertainties about the budgetary costs and distributional impacts of the outbreak....

Multi-omics evaluation of microbial co-infection as marker of COVID-19 severity -(CO-INFECTOMICS)

The main goal of this project is to understand if SARS-CoV2 co-infections are a predictive marker of disease severity in the Luxembourgish population. To achieve this, the study will compare the respiratory and stool samples of mild and severe SARS-CoV2 positive patients. Using metagenomics and metatranscriptomics, microbial profiles of the respiratory and intestinal tracts will be investigated, with a specific attention for co-infections. Moreover, individual microbial profiles will be correlated to the health parameters and immune response. We hope that the CO-INFECTOMICS project will ena...

OPEN LABEL RANDOMIZED CONTROLLED TRIAL OF THE SAFETY AND EFFICACY OF PLASMA THERAPY FROM RECOVERE...

In December 2019, the Wuhan Municipal Health Committee identified an outbreak of viral pneumonia cases of unknown cause. Coronavirus RNA was quickly identified in some of these patients. This novel coronavirus has been designated SARS-CoV-2, and the disease caused by this virus has been designated COVID-19. Currently there are no approved therapeutic agents available for coronaviruses. The purpose of this trial is to provide substantial evidence on the efficacy and safety of the treatment of selected COVID-19 patients with plasma obtained from convalescent COVID-19 patients ('PLASMA').

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