24 projects

Communication4Care

In a nutshell: Communication4Care (Com4Care) is a cloud-based communication platform to facilitate GDPR conform interoperability and link of relevant (sensor) data with structured patient-related information. No data files need to be exchanged and the platform provides a secure data storage and (real time or asynchronous) communication channel. Thus, improved standardized data acquisition, process monitoring, and data interpretation are possible. The patient can collect and report individual findings and outcomes (PROMs) and 'distribution of information' or sending of data files (electronic...

Multi-omics evaluation of microbial co-infection as marker of COVID-19 severity -(CO-INFECTOMICS)

The main goal of this project is to understand if SARS-CoV2 co-infections are a predictive marker of disease severity in the Luxembourgish population. To achieve this, the study will compare the respiratory and stool samples of mild and severe SARS-CoV2 positive patients. Using metagenomics and metatranscriptomics, microbial profiles of the respiratory and intestinal tracts will be investigated, with a specific attention for co-infections. Moreover, individual microbial profiles will be correlated to the health parameters and immune response. We hope that the CO-INFECTOMICS project will ena...

Peptide / protein /single-cell map of the renin-angiotensin system in Covid-19

Receptors for entry of SARS-CoV-2 into lung pneumocytes belong to the renin-angiotensin system and disease that are associated to a dysregulation of the same system (e.g.: diabetes, hypertension, and cardiovascular diseases) are thought to be associated with a bad Covid-19 prognosis. At the same time these receptor are also expressed on cells of the immune system and the immune system is involved in diseases associated to RAS dysregulation. Our project wish to use an integrated mass spectrometry / flow cytometry approach to build a map of the RAS at the peptide and protein level together w...

Identifying Predictors of Disease Progression and Tracking Viral Spread in COVID-19 Using Contin...

COVID-19 presents several unique challenges within cardiovascular care. While patients with preexisting CVD appear to be at an increased risk for severe disease and/or death, infection has also been shown to produce a number of CV sequelae, including cardiogenic shock and heart failure, in patients with no known CVD. Further complicating the management of cardiovascular care in COVID-19 are the adverse cardiovascular side effects produced by nearly all investigational therapies currently being tested, as well as, the unknown effects of standard care therapies used for the management of pree...

Innovative end-to-end solution for respiratory diseases detection and genotyping

Our innovative end-to-end solution for respiratory diseases detection and genotyping is composed of 3 main compoenets as follows: First, we want, through a multiplex qPCR assay, to target and differentiate in priority COVID-19, SARS, H5N1, H1N1 (devastating diseases) from seasonal flu (under control). Second, we propose to develop an NGS and SANGER assay for the following Intended uses: Respiratory diseases Genotyping, Screening, Monitoring, Quasispecies identification, Epidemiological studies. Third, we target to establish a large COVID-19 and SARS worldwide database , compare patient ...

MicroRNA biomarkers of COVID-19 severity

The Cardiovascular Research Unit of LIH proposes to apply its know-how on RNA biomarkers to identify circulating microRNAs (miRNAs) able to predict COVID-19 severity. This project is included in COVID-19 Task force WP02 and aims to fulfill the medical need of identifying patients at high risk of developing complications after infection by SARS-CoV-2 virus. The discovery of novel prognostic biomarkers will help tailoring healthcare to each individual for patient's benefit. Considering the importance of the inflammatory storm on disease severity and patient outcome, we will focus on inflamma...

HUMAN GENETIC VARIANTS AS PREDICTORS OF THE IMMUNE RESPONSE TO COVID-19

One of the main unanswered questions is why some individuals infected with COVID-19 develop severe disease, whilst others do not. Current evidence suggests that genetic variations influence human immune reactions to microbial infections, including both innate and adaptive immune responses. Here, we aim to evaluate the impact of genetic factors on the variability of the innate immune response to SARS-CoV-2 infection. On top of a large screening of the classical immune response genes (e.g. IFNs, ILs, TLRs, MHCs), we are particularly interested in the IRG1/ACOD1 gene, which we previously di...

Low-cost breath sensors for SARS-CoV-2 for home usage

Based on our research on liquid crystal droplets and shells demonstrating their responsiveness to specific substances in their surrounding, e.g. lipids, I would like to explore the possibility of making low-cost tests for SARS-CoV-2 that people can use in their home. We also make polymer fibers in our labs, and by using the right polymer, we can make a filter that a persons breathers through (mounted in, e.g., a face mask), and then the filter is dissolved in water, which is the natural surrounding for our liquid crystal droplets and spheres. If viruses have been caught in the filter, they ...

export results as excel

MESR FNR University of Luxembourg LIST LISER LIH