24 projects

Hormonal status as predictor of Covid-19 infection severity (HorCovIS)

Among people infected by COVID 19, significant disparities have been observed regarding the severity of the symptoms. Although some factors such as the presence of comorbidities have been pointed out, for another part of the patients the high severity of the symptoms remains unexplained. The HorCoVIS project aims at assessing how the hormonal status of the patients prior to infection, could be linked to symptoms severity and possibly used as a predictive tool of specific measures necessity in newly infected patients.

A novel high throughput assay to measure plasma neutralizing activity against SARS-CoV2

To date, there is no vaccine and no specific antiviral agent against SARS-CoV-2. Because of hospital saturation, controversial drug efficiency and the risk of medicinal shortage, there is an urgent need for alternative treatment options. Passive (plasmapheresis) and active immunization (vaccine) approaches aim to provide or elicit a protective humoral immune response against SARS-CoV-2. This project aims to develop a high throughput assay to measure the neutralizing activity of COVID-19 patients. It will help characterize the antibody response against SARS-CoV-2, and select the sera with hi...

Rapid serological profiling of SARS-CoV-2 antibody response

Development of antibodies is the method by which we derive immunity to a pathogen. Tracking of the development of antibodies to SARS-CoV-2 (Covid-19) is important in our understanding of this pandemic and formation of an exit strategy. Antibodies can identify different parts or proteins of a pathogen known as antigens. Current tests do not distinguish which antigens antibodies have been developed against or the level of antibody production. Using protein arrays, printed at the LIH RPPA facility we will provide a more complete analysis of the antibody development.

Xcope - Corona-Home-Control

The project is to develop an app that allows people to communicate with quarantined doctors. So you don't have to leave home if you have symptoms of a coronavirus and don't infect other people. We are building a stethoscope for the smartphone so that they can auscultate their lungs and also send it to their doctor. If we have enough data, we can also build machine learning or deep learning models to automatically detect when the coronavirus is causing pneumonia (then it becomes dangerous). This allowed people to be treated at home and only go to a hospital if the disease worsened.

Comparing the technical performances of three real-time PCR protocols to counteract the COVID-19 ...

The outbreak of SARS-CoV-2 infections has underlined the critical value of laboratory diagnosis in order to quickly identify infected-patients, to provide optimized care, and to limit COVID-19 transmission. Several real-time RT-PCR diagnostic assays were rapidly developped, in particular by pharmaceutical companies which were Conformité Européenne (CE) marked. Since all countries are currently facing reagent shortages that limit the testing capacity, several real-time PCR assays were established to counteract the COVID-19 outbreak by using different techniques and suppliers, such as in Lu...

Development of a high performance COVID-19 immunoassay to assess population-based viral immunity

The current situation of lock-down in many countries creates a strong need for large screening efforts in order to assess the immune status of the population and to advice decision makers on measures to relaunch social and economic activites. Due to the need for serological testing on high numbers of individuals over several months, shortages are predictable and a major threat to society. The present proposal aims at the setup of a diagnostic assay using an immunodetection technique and recombinant viral surface proteins expressed and purified in Luxembourg. This assay will allow Luxembourg...

Cell-cell interaction model of COVID19 for potential interventions

The emergence of COVID-19 pandemic implies new challenges for the Health Systems worldwide. The great majority of COVID-19 infections are mild and self-limiting in nature. Nevertheless, a small percentage of the patients require hospitalisation and specialised attention in Intensive Care Units (ICUs). The role of host immune responses in clearance of COVID-19 or the role, if any, of host immune responses in contributing to severe respiratory pathogenesis of COVID-19 infections is not known at this time. There are previously identified specific host immune response chemokine and cytokine sig...

Relation of severity of COVID-19 infection to nutrient status, oxidative stress, inflammation & v...

Background: Severity of COVID-19 infection is related to host-factors including the immune and respiratory system, gut health, and pre-existing cardio-metabolic diseases. Enhanced inflammation and oxidative stress may worsen the prognosis of COVID-19 subjects. An imbalanced diet poor in essential micronutrients, dietary fiber and phytochemicals and containing insufficient proteins and antioxidant properties can aggravate these aspects, worsening the immune system and infection risk, especially in conjunction with enhanced visceral adiposity exacerbating chronic inflammation. Individuals wit...

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