24 projects
Status
Domain
Organization Type
COVID-19 and chronic diseases: national health care provider survey
COVID-19 is placing unprecedented pressures on healthcare systems. The current declared pandemic has urged healthcare professionals to reorganise profoundly their everyday practice while trying to maintain care for other patients. Since the 'lockdown' situation in Luxembourg, changes in the medical sector include the opening of advanced care centres, promotion of teleconsultations and restrictions on non-urgent health care. Pre-existing chronic diseases such as cancer, cardiovascular and respiratory disease are reported as being major risk factor for severe COVID-19 health outcomes (Jordan ...
COVI-NUTRI-METABOLOMICS
Background: A poor nutrient status due to sub-optimal dietary habits increases risk of viral infections. In particular, individuals with low vitamin D, A and E, as well as zinc plasma levels are less likely to develop immune-responses against influenza vaccines. Vitamin C supplementation improves conditions in individuals with acute respiratory infections in some studies. Dietary fiber is inversely correlated with mortality from respiratory/infectious disease. These nutrients are paramount for optimal immune-response, are implicated in oxidative stress, inflammatory processes, and viral rep...
iTECare
Nosocomial infection represents (at European level) 5 million cases, 135,000 deaths with a cost between 13 and 24 billion euros. iTECare is a startup dedicated to develop, produce and distribute ecological disinfection solutions facilitating decontamination, ensuring employee safety, reassuring clients and avoiding new outbreaks • UV-C desinfection lamps able to sterilize in 2 minutes (instead of 20 minutes) an hospital room, hotel room, a meeting room, an office, a cloths shop. The UV-C lamp emits very useful ultraviolet radiation at the wavelength of 253.7 nm, which destroys the DNA & ...
Covid-19 related LOckdown: Shift in Exposures to neighbourhood environments and changes in Physic...
A lockdown state implies radical changes in our lifestyle, especially physical activity (PA), while PA plays a central role in maintaining an adequate health status, counteracting the negative consequences of numerous diseases. We aim to investigate the impact of lockdown (and quarantine) on PA patterns based on retrospective data. We will analyse the intra-individual changes in PA patterns of participants stratified in two specific subgroups of interest, namely positive cases and their household members as a result of the lockdown/quarantine measures in place, with respect to the partici...
BioOrg eliminate the virus on surfaces and weaken spreading
BioOrg is a natural ecosystem initially destined to purify indoor air quality and facilitate natural cleaning. It is made of bacteria naturally present in our forest. No allergens, no additives except perfume for a safe use in all environment. Very simple : fine spraying in indoor spaces (buildings, vehicles, homes) will create a natural ecosystem. Bacteria in the solution will digest fine particles (aggressive to the lungs and carrier of COVID-19), solvants, and other indoor polluters. Bacillius bacteria are known for years to dry out surfaces by digesting biomass, thus creating a hostil...
Leveraging Systems Biology to Target Hyperinflammation in COVID-19
The emergence of COVID-19 pandemic implies new challenges for the Health Systems worldwide. A small percentage of the patients require hospitalisation and specialised attention in Intensive Care Units (ICUs). Furthermore, accumulating evidence suggests that a subgroup of patients with severe COVID-19 might have a cytokine storm syndrome. Therefore, the main goal of the proposal is to elucidate the potential role of cytokine storm in COVID-19 disease severity, and to propose novel strategies for counteracting this hyperinflammatory response. In this context, we propose to develop a single...
Cytokines as biomarkers and therapeutic targets in COVID-19 infection
Cytokines play an important role in the pathogenesis of COVID-19 infection. A subgroup of patients develops a cytokine storm syndrome, correlating with a bad clinical outcome. For example, the concentration of the inflammatory cytokine Interleukin-6 (IL-6) has been recognized as a risk factor for mortality and for respiratory failure in Chinese and German patient cohorts, respectively. Tocilizumab, an antibody directed against the IL-6 receptor alpha chain, is used in clinical trials as well as an FDA-approved inhibitor of Jaks, tyrosine kinases which mediate the signal transduction of mult...
Predicting the disease severity by analyzing the novel coronavirus SARS-CoV-2 quasispecies in in...
Viruses, particularly RNA viruses, possess a great capability to evolve and mutate in order to rapidly respond to host immune selection pressure. Consequently, they generate a population with a large number of variable but closely related genomes, also known as quasispecies in the host. Accurate characterization of low-frequency variants could provide invaluable aid in clinical decision making as demonstrated for many other single-strand RNA viruses. Understanding of the correlation of SARS-CoV-2 quasispecies complexity with the disease severity might help us to stratify COID-19 patients an...
